Rac Inhibitor III, EHop-016

Size

£415.00

SKU:: 217731
Molecular Weight:: 430.6
Purity:: ≥96% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1380432-32-5
Format:: Pale yellow powder
Extra Details:: A cell-permeable NSC23766 analog that is more selective against Rac interaction with Vav2 (by 45% blockage at 4uM) than Tiam (35% blockage at 50uM) and ~100-times more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 (IC50=1.1 vs. 95uM, respectively) cultures. Effectively inhibits PAK Thr423 phosphorylation (IC50 <2uM), while reducing Cdc42-GTP level only at higher concentrations (by 18% at 5uM), in MDA-MB-435 cultures. Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells. Synonyms: N⁴-(9-Ethyl-9H-carbazol-3-yl)-N²-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine CAS No: 1380432-32-5 Molecular Formula: C₂₅H₃₀N₆O Solubility: DMSO Molecular Weight: 430.6 Purity: ≥96% (HPLC) Appearance: Pale yellow powder Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.