Pre-mRNA Splicing Inhibitor, Isoginkgetin

Size

£546.00

SKU:: 217696
Molecular Weight:: 566.5
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 548-19-6
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax=50uM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33uM for 24h). 217696 is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Synonyms: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one CAS No: 548-19-6 Molecular Formula: C₃₂H₂₂O₁₀ Molecular Weight: 566.5 Solubility: DMSO (100mg/ml) Appearance: Supplied as a yellow solid. Purity: ≥98% (HPLC) Storage and Stability: Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.