PPARbeta/delta Antagonist, PT-S58 (PPARb Antagonist II, Methyl 3-(N-(4-(tert-butylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate, PPARd Antagonist II)

Size

£429.00

SKU:: 217692
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a dark yellow solid.
Extra Details:: A cell-permeable, diaryl sulfonamide PPARb/d subtype-specific pure competitive antagonist with an IC50 of 98nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARb/d specific agonist-induced transcriptional activity in cell cultures. Formula: C17H22N2O5S2 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.