PP1 Analog IV, 3-IB-PP1 (3-Iodobenzyl PP1 Analog)

Size

£550.00

SKU:: 217685
Molecular Weight:: 407.3
Purity:: ≥97% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1174182-24-1
Format:: Supplied as a white to yellow solid.
Extra Details:: A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50=28, 240 and 120nM, respectively) over wtAkt1/2/3 (IC50= >10uM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3bSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5uM) and rapidly activates T cell receptor signaling. CAS No: 1174182-24-1 Molecular Formula: C16H18IN5 Molecular Weight: 407.3 Appearance: Supplied as a white to yellow solid. Purity: ≥97% (HPLC) Solubility: DMSO (0.5mg/ml) Storage and Stability: May be stored at 4°C. Stable for 6 months after receipt. Reconstitute with DMSO. For maximum recovery of product, centrifuge the original vial prior to removing the cap.