Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide)

Size

£512.00

SKU:: 217683
Molecular Weight:: 379.45
Purity:: ≥99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1243243-89-1
Format:: Supplied as an off-white powder.
Extra Details:: A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide, Wnt-C59, Wnt Pathway Inhibitor XVI CAS No: 1243243-89-1 Molecular Formula: C₂₅H₂₁N₃O Molecular Weight: 379.45 Solubility: DMSO (100mg/ml) Primary Target: Porcupine (Porcn)-mediated Wnt palmitoylation Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.