PON1 Activator (ZNPA, (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile)

Size

£442.00

SKU:: 217682
Molecular Weight:: 295.3
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 42172-66-7
Format:: Supplied as a pale yellow solid.
Extra Details:: A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50=1uM) and inducer of PON1 enzymatic activity (>3-fold at 5um) when compared to resveratrol. However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cytochrome P4501A1 (CYP1A1). CAS No: 42172-66-7 Formula: C₁₅H₉N₃O₄ Molecular Weight: 295.3 Solubility: DMSO (25mg/ml, pale yellow solution) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Light Sensitive.