Polo-like Kinase Inhibitor V, Poloxin (2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone)

Size

£372.00

SKU:: 217681
Molecular Weight:: 297.4
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 321688-88-4
Format:: Supplied as a yellow solid.
Extra Details:: A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50)=4.8uM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25uM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40mg/kg. CAS Number: 321688-88-4 Formula: C₁₈H₁₉NO₃ Molecular Weight: 297.4 Solubility: DMSO (25mg/ml, clear, yellow solution) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.