PK11195

Size

£381.00

SKU:: 217669
Molecular Weight:: 352.86
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 85532-75-8
Format:: Supplied as a white solid.
Extra Details:: An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100uM). Synonyms: TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195 CAS No: 85532-75-8 Molecular Formula: C₂₁H₂₁ClN₂O Molecular Weight: 352.86 Solubility: DMSO Primary Target: peripheral bezodiazepine receptor Primary Target Ki: 20nM Appearance: Supplied as a white solid. Purity: ≥98% (HPLC) Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.