PICK1 PDZ Domain Inhibitor, FSC231 ((E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate)

Size

£491.00

SKU:: 217658
Molecular Weight:: 313.1
Purity:: ≥95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as an off-white solid.
Extra Details:: A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10uM), GluR2 (Ki ~10uM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons. Formula: C₁₃H₁₀Cl₂N₂O₃ Molecular Weight: 313.1 Solubility: DMSO (100mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.