PI 3,4-K Inhibitor, PIK-93 (N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide)

Size

£526.00

SKU:: 217657
Molecular Weight:: 389.9
Purity:: ~98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 593960-11-3
Format:: Supplied as a pale yellow solid.
Extra Details:: A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50=16, 19, 39 and 64nM for p110y, PI 4-KIIb, p110a and DNA-PK, respectively). Moderately inhibits p110d, PI 3-KC2b, hsVPS34, ATM, p110b and PI 4-KIIIa (IC50=0.120, 0.140, 0.320, 0.490, 0.590 and 1.1uM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50>10uM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250nM. CAS Number: 593960-11-3 Formula: C14H16ClN3O4S2 Solubility: DMSO Molecular Weight: 389.9 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.