p38 MAP Kinase Inhibitor X, BIRB 796 (1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII)

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£479.00

SKU:: 217617
Molecular Weight:: 527.7
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 285983-48-4
Extra Details:: A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50=8 and 97nM, respectively, against human p38a, respectively, with or without 2h preincubation), but high affinity (t1/2 of dissociation from human p38a=23h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2a2 and c-Raf-1 only at much higher concentrations (IC50 =98nM and 1.4uM, respectively) and displays little or no activity toward 10 other kinases (IC50 >20uM). Shown to inhibit LPS-induced TNF-a production both in vitro (IC50 =18 and 780nM using THP-1 cells and in human whole blood, respectively) and in mice in vivo (by 84%; 30mg/kg p.o.). Synonyms: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII, Doramapimod, BIRB796 CAS No: 285983-48-4 Molecular Formula: C₃₁H₃₇N₅O₃ Molecular Weight: 527.7 Solubility: DMSO Appearance: White solid. Purity: ≥97% (HPLC) Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.