L002 (p300/CBP Inhibitor VI)

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£359.00

SKU:: 217616
Molecular Weight:: 321.3
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 321695-57-2
Extra Details:: L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro). It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3. It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime] CAS No: 321695-57-2 Molecular Formula: C₁₅H₁₅NO₅S Molecular Weight: 321.3 Solubility: DMF (30mg/ml) DMSO (30mg/ml) DMSO:PBS(pH 7.2) (1:2) (0.25mg/ml) Ethanol (1mg/ml) Purity: ≥98% Form: Supplied as a crystalline solid Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.