217603
NS8593 ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine)
Size
£505.00
- SKU:
- 217603
- Molecular Weight:
- 263.34
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 875755-24-1
- Extra Details:
- An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; =420nM, 600nM, and 730nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50=1.6mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. Synonyms: NS8593; ((R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine; N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride) CAS No: 875755-24-1 Free Base: 875755-39-8 Molecular Formula: C₁₇H₁₇N₃•HCl Molecular Weight: 263.34+(36.46) Purity: ≥98% Appearance: White powder Solubility: DMSO (100mg/ml) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Hygroscopic. Keep tightly closed and desiccated under inert atmosphere. Light sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice