NS 1738

Size

£403.00

SKU:: 217602
Molecular Weight:: 365.1
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 501684-93-1
Extra Details:: NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 µM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test.1 NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways. Synonyms: N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-urea CAS No: 501684-93-1 Molecular Formula: C14H9Cl2F3N2O2 Molecular Weight: 365.1 Solubility: DMSO, DMF, Ethanol Purity: ≥98% Form: Supplied as a crystalline solid Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.