NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm)

Size

£393.00

SKU:: 217592
Purity:: ~97% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as a yellowish-white powder.
Extra Details:: An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Solubility: DMSO Primary Target: NMDA Primary Target IC50: 0.31u Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.