Neuroprotectant, OBA-09 (2-(2-Oxopropanoyloxy)Benzoic Acid)

Size

£415.00

SKU:: 217585
Molecular Weight:: 208.2
Purity:: ~99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a white solid.
Extra Details:: A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-kB activity by reducing IkB-a degradation. Formula: C10H8O5 Molecular Weight: 208.2 Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.