mu delta Opiod Receptor Agonist, CYM51010 (CID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate)

Size

£408.00

SKU:: 217573
Purity:: ≥90% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1069498-96-9
Format:: Supplied as a white solid.
Extra Details:: A cell-permeable, blood-brain barrier permeant, non-toxic phenethylpiperidine compound that binds reversibly and with high affinity to the uOR-deltaOR-heteromer. Exhibits a robust beta-arrestin recruitment activity (EC50 = 8.3uM; Emax = 1,197% over basal), which is at least two to three-fold higher than that obtained with ubetagalOR (EC50 = 1.8uM; Emax = 557%) or deltabetagalOR (EC50 = 2.7uM; Emax = 423%) alone. Induces a strong increase in [35S]GTPupsilonS binding (EC50 = 54, 210, and 300nM; and Emax (% basal) = 168, 138 and 113 for with ubetagalOR-deltaOR, ubetagalOR and deltabetagalOR, respectively). Potentiates antinociceptive activity similar to morphine (10mg/kg, s.c. in a tail-flick assay) with less side effects and dependency. However, chronic administration of CYM51010 results in reduced antinociceptive tolerance compared with morphine. Synonyms: CID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate CAS Number: 1069498-96-9 Molecular Formula: C₂₅H₃₂N₂O₃ Solubility: DMSO Primary Target: muOR-deltaOR-heteromer Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice