Mitochondrial Pyruvate Carrier Inhibitor, UK5099

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£347.00

SKU:: 217555
Molecular Weight:: 288.3
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 56396-35-1
Extra Details:: A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Synonyms: ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid; (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid; MPC Inhibitor; PF-1005023) CAS No: 56396-35-1 Molecular Formula: C₁₈H₁₂N₂O₂ Molecular Weight: 288.30 Purity: ≥98% (HPLC) Appearance: Bright yellow solid Solubility: DMSO (100g/ml). Use fresh DMSO for reconstitution Primary Target: Mitochondria Method for Determining Identity: Proton NMR Spectroscopic and LC-MS Spectrometric Analysis Carbon: As Reported Hydrogen: As Reported Nitrogen: As Reported Water: As Reported Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at 4°C. Do not freeze. Reconstitute with DMSO. Store at 4°C.