Midkine Inhibitor, iMDK (MDK Expression Inhibitor, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl)-2H-chromen-2-one)

Size

£415.00

SKU:: 217548
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an off-white solid.
Extra Details:: A cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48h at 25nM) via a yet unidentified mechanism. Shown to inhibit the viability of MDK-positive HEK293, H441, and H520 cells (by ≥60% at 500nM in 48h), but not MDK-negative NHLF or HEK293 (by <15% at 500nM in 48h), via apoptosis induction as a result of PI 3-K/AKT signaling inhibition. Intraperitoneal injection is reported to be efficacious in retarding H441 tumor expansion in mice (9mg/kg; 3X to 5X per wk) in vivo. Primary Target: Midkine Molecular Formula: C₂₁H₁₃FN₂O₂S Solubility: DMSO Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.