Methysergide Maleate (5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491)

Size

£393.00

SKU:: 217546
Molecular Weight:: 469.54
Purity:: ≥99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 129-49-7
Format:: Supplied as an off-white solid.
Extra Details:: An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18uM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments. CAS Number: 129-49-7 Molecular Formula: C₂₁H₂₇N₃O₂·C₄H₄O₄ Solubility: H2O Primary Target: 5-HT Molecular Weight: 469.54 Appearance: Supplied as an off-white solid. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.