MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one)

Size

£495.00

SKU:: 217535
Molecular Weight:: 581.5
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 675576-98-4
Format:: Supplied as a white powder.
Extra Details:: A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Synonyms: (-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one CAS Number: 675576-98-4 Molecular Formula: C₃₀H₃₀Cl₂N₄O₄ Solubility: DMSO Molecular Weight: 581.5 Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.