LY 83583 (LY83583, 6-Anilino-5,8-quinolinequinone)

Size

£315.00

SKU:: 217526
Molecular Weight:: 250.2
Purity:: ~98% (TLC, HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 91300-60-6
Format:: Supplied as a reddish purple solid.
Extra Details:: A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50=2uM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. CAS Number: 91300-60-6 Formula: C15H10N2O2 Solubility: EtOH Primary Target: Soluble guanylate cyclase Primary Target IC50: 2uM Molecular Weight: 250.2 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.