LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864)

Size

£415.00

SKU:: 217523
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 186544-26-3
Format:: Supplied as a white solid.
Extra Details:: A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935. CAS Number: 186544-26-3 Molecular Formula: C₂₁H₂₂FN₃O·HCl Solubility: DMSO or H2O Primary Target: 5-HT1F Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.