LSD1 Inhibitor IV, RN-1,HCl (2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, Lysine (K)-Specific Demethylase Inhibitor IV,RN-1,HCl, BHC110 Inhibitor IV, KDM1 Inhibitor IV, MOA Inhibitor III)

Size

£672.00

SKU:: 217521
Molecular Weight:: 416
Purity:: ≥97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable tranylcypromine (parnate) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50=70nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 =0.51 and 2.785uM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10mg/kg, i.p.). Molecular Formula: C₂₃H₂₉N₃O₂•2HCl Solubility: DMSO or H2O Molecular Weight: 416 Storage and Stability: Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.