Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine)

Size

£386.00

SKU:: 217514
Molecular Weight:: 335.3
Purity:: ~99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a white solid.
Extra Details:: A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Formula: C16H16F3N5 Molecular Weight: 335.3 Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.