IRTK Activator III, DDN (5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquino)

Size

£386.00

SKU:: 217468
Molecular Weight:: 343.1
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a pale yellow-green powder.
Extra Details:: An orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5uM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20mg/kg, p.o.). Formula: C14H8Cl2O6 Molecular Weight: 343.1 Solubility: DMSO (25mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.