ICMT Inhibitor II, FTPAT

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£593.00

SKU:: 217448
Molecular Weight:: 449.6
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1350561-58-8
Extra Details:: A cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50=800nM; Ki=400nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50=33 and >100uM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50=8uM). Synonyms: (E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate CAS No: 1350561-58-8 Molecular Formula: C₂₆H₃₁N₃O₂S Molecular Weight: 449.6 Solubility: DMSO (50mg/ml) Purity: ≥98% (HPLC) Appearance: White solid Storage and Stability: Store at -20°C under inert atmosphere. Stable for 6 months after receipt.