Hsp70 Activator, YM-1

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£581.00

SKU:: 217443
Molecular Weight:: 417.98
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 409086-68-6
Extra Details:: A stable and soluble MKT-077 analog that acts an allosteric activator of heat-shock protein 70 (HSP70). Its action appears to be similar to HSP70 interacting protein (HIP). Shown to convert HSP70 to its tight-affinity conformation and promote the accumulation of the ADP-bound form of HSP70. Increases the binding of HSP70 to its unfolded substrates . Also shown to enhance ubiquitination and degradation of nNOS and polyglutamine androgen receptor (polyQ AR) (at ~1mM). Displays selective cytotoxicity across multiple cancer cell lines without affecting the normal cells. Also reported to restore tamoxifen sensitivity to a refractory tamoxifen-resistant MCF7 cells (~10mM). Synonyms: YM-01, Heat Shock 70 kDa Protein Activator, Hsp70 Chemical Co-Chaperone, YM1, YM01, 2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride, 2-[3-Ethyl-5-(3-methyl-3H-benzothiazol-2-ylidene)-4-oxo-thiazolidin-2-ylidenemethyl]-1-methyl-pyridinium chloride CAS No: 409086-68-6 Molecular Formula: C₂₀H₁₉N₃OS₂•HCl Molecular Weight: 417.98 Solubility: DMSO Appearance: Orange red solid Purity: ≥98% (HPLC) Storage and Stability: Storage at -20°C under inert gas. Light sensitive.