Histone Acetyltransferase Inhibitor VIII, NU9056

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£524.00

SKU:: 217428
Molecular Weight:: 232.37
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1450644-28-6
Extra Details:: A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Primary Target: KAT5 Synonyms: HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V, 1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I CAS No: 1450644-28-6 Molecular Formula: C₆H₄N₂S₄ Molecular Weight: 232.35 Appearance: Liquid in DMSO (10mg/ml) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis Storage and Stability: Long-term storage is recommended at -20°C. Stable for 6 months after receipt.