HIF Inhibitor V ((E)-3-(3-(4-Adamantan-1-ylphenoxy)acrylamido)benzoic Acid Morpholinoethyl Ester, Hypoxia-Inducible Factor Inhibitor V)

Size

£415.00

SKU:: 217424
Molecular Weight:: 530.7
Purity:: ~99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as a white powder.
Extra Details:: A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1alpha accumulation in a manner similar to LW6 by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120nM vs 2.44uM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2uM) under hypoxia conditions. Molar Mass: 530.7 Solubility: DMSO Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.