GPR109b Agonist (1-(iso-Propyl)-1H-benzotriazole-5-carboxylic Acid)

Size

£395.00

SKU:: 217391
Molecular Weight:: 205.2
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 306935-41-1
Format:: Supplied as a light brown solid.
Extra Details:: A cell-permeable Niacin triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or b-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5uM) and isoproterenol (1uM), respectively, in GPR109b-expressing CHO cells (EC50=400nM) and freshly isolated human adipocytes (EC50 about 1uM). Formula: C10H11N3O2 Solubility: DMSO (50mg/ml), Ethanol (2mg/ml) Molecular Weight: 205.2 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.