Glucagon-Like Peptide 1 Receptor Agonist

Size

£518.00

SKU:: 217385
Molecular Weight:: 348.3
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 281209-71-0
Format:: Yellow solid
Extra Details:: A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50=101nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin. Synonyms: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB); Compound 2; GLP-1R Agonist CAS Number: 281209-71-0 Molecular Formula: C₁₃H₁₅Cl₂N₃O₂S Molecular Weight: 348.3 Purity: ≥98% (HPLC) Solubility: DMSO (20mg/ml), Ethanol (10mg/ml) Storage and Stability: Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.