Flumazenil (GABAA Receptor Antagonist, Flumazenil, Ro 15-1788)

Size

£333.00

SKU:: 217359
Purity:: ≥99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 78755-81-4
Format:: White solid.
Extra Details:: A competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200ug/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter. Synonyms: GABAA Receptor Antagonist, Flumazenil, Ro 15-1788, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester CAS No: 78755-81-4 Molecular Formula: C₁₅H₁₄FN₃O₃ Solubility: DMSO Primary Target: GABA-A Purity: ≥99% (HPLC) Appearance: White solid. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.