FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3’–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester)

Size

£382.00

SKU:: 217352
Molecular Weight:: 354.4
Purity:: ≥95% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as a gray-white powder.
Extra Details:: A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Formula: C20H22N2O4 Solubility: DMSO Molar Mass: 354.4 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.