217347
ERO1 Inhibitor I, Erodoxin (Endoplasmic Reticulum Oxidase 1 Inhibitor, 1-Bromo-5-methoxy-2,4-dinitrobenzene)
Size
£581.00
- SKU:
- 217347
- Molecular Weight:
- 277
- Purity:
- ≥99% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a yellow solid.
- Extra Details:
- A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1a (IC50=400uM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells. Molecular Formula: C₇H₅BrN₂O₅ Molecular Weight: 277 Solubility: DMSO (100mg/ml) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice