Elastase Inhibitor V (2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one)

Size

£429.00

SKU:: 217338
Molecular Weight:: 336.6
Purity:: ~99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an off-white solid.
Extra Details:: A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8nM), but not O2•- generation, in fLMP-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1mg/kg, i.v.). Solubility: DMSO Primary Target: Elastase Molar Mass: 336.6 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.