DUB Inhibitor V, PR-619

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£499.00

SKU:: 217329
Molecular Weight:: 223.3
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 21645-32-1
Extra Details:: A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150uM; 0.5 to 20h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains. Synonyms: PR619; UCH-L1 Inhibitor IV; UCH-L3 Inhibitor II; UCH-L5/UCH37 Inhibitor III; USP5 Inhibitor II; USP7 Inhibitor I; USP9X Inhibitor II; USP14 Inhibitor IV; USP14 Inhibitor IV; USP47 Inhibitor I; 2,6-Diaminopyridine-3,5-bis(thiocyanate); 3,5-Dithiocyanatopyridine-2,6-diamine CAS No: 21645-32-1 Molecular Formula: C₇H₅N₅S₂ Molecular Weight: 223.3 Purity: ≥99% (HPLC) Appearance: Tan solid Solubility: DMSO (50mg/ml) Proton NMR: Conforms LC-MS: Conforms Carbon: 35-38% Hydrogen: 1.5-3.5% Nitrogen: 29-32% Sulfur: 27-30% Water by CHN (mol): ≤2mol Storage and Stability: Store at 4°C. Stable for 6 months after receipt.