Daminozide (JHDM Inhibitor VI, N,N-Dimethylamino-succinamic Acid, Succinic Acid-2,2-dimethylhydrazide, 4-(2,2-Dimethylhydrazinyl)-4-oxobutanoic Acid, BHC100 Inhibitor VI, KDM2A Inhibitor, KIAA1718 Inhibitor VI, LSD Inhibitor VI, PHF8 Inhibitor, Histone Lysine Demethylase Inhibitor XII, LSD1 Inhibitor VI)

Size

£274.00

SKU:: 217311
Molecular Weight:: 160.2
Purity:: ≥98% (NMR)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1596-84-5
Format:: Supplied as a white powder.
Extra Details:: A dimethylamino substituted succinamate that, in addition to its well known use as a plant growth regulator, also acts as an inhibitor against histone lysine demthylases KDM2A, LSD1 (KDM7A; KIAA1718), and PHF8 (IC50 = 1.5, 2.1, and 0.55uM, respectively), but not KDM3A, KDM4E, KDM5C, KDM6B, or three hydroxylases (IC50 >100uM). Substrate-competition and/or active site Iron chelating likely accounts for the inhibitory activity against the FAD-dependent LSD1, while 2-oxoglutarate (2-OG) competition (Ki = 1.97uM) appears as the major mode of action against KDM2A. CAS Number: 1596-84-5 Formula: C6H12N2O3 Solubility: H2O Molar Mass: 160.2 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.