Cytoplasmic Dynein Inhibitor, Ciliobrevin D (2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile)(AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor)

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£581.00

SKU:: 217307
Molecular Weight:: 392.6
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1370554-01-0
Extra Details:: A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10-40uM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling. Synonyms: 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor CAS No: 1370554-01-0 Molecular Formula: C₁₇H₈Cl₃N₃O₂ Molecular Weight: 392.6 Solubility: DMSO (2.5mg/ml) Form: Supplied as an orange powder. Purity: ≥99% (HPLC) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.