CX3CR1, Extracellular Loop (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)

Size

£672.00

SKU:: 217294
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to the extracellular loop of human CX3CR1. Epitope: aa160-210. Species sequence homology: mouse, rabbit, bovine and rat.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine. CX3CR1 mediates leukocyte migration and adhesion. Applications: Suitable for use in Western Blot, Immunofluorescence, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml, detects a band at ~50kD. Immunohistochemistry (paraffin): 10ug/ml Immunofluorescence: 20ug/ml Optimal dilutions to be determined by the researcher. Positive Control: THP-1 cell lysate, 3T3 cell lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice