CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide)

Size

£453.00

SKU:: 217284
Molecular Weight:: 418.3
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a light beige solid.
Extra Details:: A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies. Alternate Name: N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide Molecular Formula: C₁₇H₉F₇N₄O Primary Target: Orai3 Primary Target IC50: 490nM Molar Mass: 418.3 Solubility: DMSO Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.