CGP 35348 (GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348)

Size

£386.00

SKU:: 217271
Purity:: ~98% (TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 123690-79-9
Format:: Supplied as a white solid.
Extra Details:: A selective antagonist of post-synaptic GABAB receptors (IC50 = 34uM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices. CAS Number: 123690-79-9 Primary Target: GABA-B Primary Target IC50: 34u Solubility: H2O Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.