Cdc42/Rac1 GTPase Inhibitor, ML141 (MLS00693334, CID2950007, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II)

Size

£512.00

SKU:: 217263
Molecular Weight:: 407.5
Purity:: ~99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a yellow-white solid.
Extra Details:: A cell-permeable trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50=0.2, 2.6 and 5.4uM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50>100uM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPyS and PAK-PBD, and decrease GTP-Cdc42 (>95%) and GTP-Rac1 (>40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin-induced filopodia formation in 3T3 cells at 10uM. CAS Number: 71203-35-5 Formula: C22H21N3O3S Solubility: DMSO Molecular Weight: 407.5 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.