CDC42 Inhibitor III, ZCL278 (4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)acetamide, CDC42 GTPase Inhibitor III)

Size

£442.00

SKU:: 217262
Molecular Weight:: 584.89
Purity:: ~94% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 587841-73-4
Format:: Supplied as a light beige solid.
Extra Details:: A cell-permeable, non-cytotoxic, aqueous soluble (181uM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1h pretreatment; 50uM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50uM). Synonyms: 2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide CAS No: 587841-73-4 Molecular Formula: C₂₁H₁₉BrClN₅O₄S₂ Solubility: DMSO Primary Target: CDC42 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.