Cdc2-Like Kinase Inhibitor IV (KH-CB19)

Size

£315.00

SKU:: 217260
Molecular Weight:: 338.2
Storage Conditions:: -70°C
Supplier:: United States Biological
CAS Number:: 1354037-26-5
Extra Details:: A cell-permeable N-methylindolyl-enaminonitrile compound that acts as a potent, non-ATP mimetic binding and reversible inhibitor of Clk1 and Dyk1A (IC50=19.7 and 55.2nM, respectively) with moderate to excellent selectivity over Clk3 (IC50=530nM) and against 71-kinases. Shown to suppress phosphorylation of Ser/Arg-rich (SR) proteins, regulate alternative splicing and lower both full-length and alternatively spliced human tissue factor isoforms much more efficiently than Cdc2-Like Kinase Inhibitor, TG003 in HMEC-1 cells. Synonyms: (E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, Clk Inhibitor IV Molecular Formula: C₁₅H₁₃Cl₂N₃O₂ Molecular Weight: 338.2 Purity: ≥99% (HPLC) Appearance: Off-white to light yellow solid Solubility: DMSO (50mg/ml) Method for Determining Identity: Proton NMR and Liquid Chromatography-Mass Spectrometry Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -80°C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.