CBF beta-Runx1 Inhibitor II (Ro5-3335)

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£531.00

SKU:: 217258
Molecular Weight:: 259.69
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 30195-30-3
Extra Details:: A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Synonyms: ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one]; Ro53335; CBFalpha-CBFbeta Inhibitor II) CAS No: 30195-30-3 Molecular Formula: C13H10ClN3O Molecular Weight: 259.69 Purity: ≥98% (HPLC) Appearance: White to off-white powder Solubility (50mg/ml): DMSO Elemental Analysis: Calculated: %C: 58.5-60.5 %H: 3.5-5.0 %N: 15-16.5 Water Content (by Elemental Analysis): ≤1mol Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.