BCRP Inhibitor IV, YHO-13351 (Diethylaminoacetic Acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate)

Size

£553.00

SKU:: 217212
Molecular Weight:: 579.7
Purity:: ≥97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Yellow solid.
Extra Details:: An in vivo bioavailable (~87%; t1/2 <5 mins. during p.o. and i.v. administration) and highly water soluble ( >100mg/ml) diethylaminoacetate prodrug of YHO-13177 that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200mg/kg, i.p.). Synonyms: Diethylaminoacetic acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate Formula: C₂₆H₃₃N₃O₄S • CH₃SO₃H Molecular Weight: 579.7 Solubility: H2O (25mg/ml) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.