217170
Akt Inhibitor XIX, 3CAI (2-Chloro-1-(1H-indol-3-yl)-ethanone, 3-Chloroacetyl-indole)
Size
£397.00
- SKU:
- 217170
- Molecular Weight:
- 193.6
- Purity:
- ≥98% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 28755-03-5
- Format:
- Supplied as a pink solid.
- Extra Details:
- A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1uM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4uM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50=30mg/kg; 5 times/wk for 3 wks via p.o.) in vivo. CAS Number: 28755-03-5 Formula: C₁₀H₈ClNO Molecular Weight: 193.6 Solubility: DMSO (100mg/ml) Purity: ≥98% (HPLC) Appearance: Supplied as a pink solid. Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice