AKR1C1 Inhibitor, 5-PBSA

Size

£581.00

SKU:: 217167
Molecular Weight:: 293.1
Purity:: ≥94% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 4906-68-7
Format:: White solid.
Extra Details:: A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki=4nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki=0.087, 4.2 and 18.2uM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50=460nM in AKR1C1 overexpressing BAECs). Synonyms: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA CAS No: 4906-68-7 Molecular Formula: C₁₃H₉BrO₃ Solubility: DMSO NMR: Conforms LC-MS: Conforms Purity: ≥94% (HPLC) Appearance: White solid. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.