217163
AhR Agonist V, VAF347
Size
£505.00
- SKU:
- 217163
- Molecular Weight:
- 349.7
- Storage Conditions:
- 4°C Do not freeze
- Supplier:
- United States Biological
- CAS Number:
- 574759-62-9
- Extra Details:
- A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Synonyms: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine CAS No: 574759-62-9 Molecular Formula: C₁₇H₁₁ClF₃N₃ Molecular Weight: 349.7 Purity: ≥99% (HPLC) Appearance: White solid Solubility: DMSO (50mg/ml) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis Storage and Stability: Powder is stable for 6 months after receipt at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice